Imaging

The NIHR Imperial BRC aims to ensure advances in imaging technology have an immediate impact, by developing innovative technologies within our imaging centres and implementing them in experimental medicine studies.
There is a clear clinical need to improve our ability to predict, diagnose and monitor disease. Advanced medical imaging enables us to view organ anatomy, molecular targets and biochemical processes in living subjects, in intricate detail. This makes it possible to identify disease biomarkers, make more accurate diagnoses and predict a patient’s response to treatment.

With innovative medical imaging we are able to provide detailed information to enable better decision making in the clinic. Our imaging facilities, which provide core technologies such as Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), and ultrasound, include:

  • The IC Clinical Imaging Facility (ICCIF), which has the highest capacity for conducting BRC research in imaging sciences in PET and MRI;
  • The Pan-London (Imperial-Kings-UCL and MRC) Imaging Facility, Imanova, which provides access to innovative radiopharmaceuticals for PET imaging and houses the Imperial College Dementia Platform (DP)UK PET-MR scanner;
  • The MRC Mansfield Centre, which is where the most innovative cardiovascular work and MRI takes place.

We work in four main areas:

Biomarkers for disease diagnosis

Combined with other methods, advanced imaging techniques can help us predict disease earlier. For example, we can generate dynamic 3D representations of the human heart using cardiac magnetic resonance imaging. When combined with genetic sequencing, this provides a genetic model that enables us to diagnose patients with heart disease and identify biomarkers of disease in their relatives.

Biomarkers to predict responses to treatment

With anatomical and functional imaging we can assess how a disease is progressing and how a patient is responding to treatment, paving the way to personalised medicine. Our work in combining different radiopharmaceuticals for the assessment of inflammation, tau and amyloid pathology will enable us to assess therapy response in Alzheimer’s disease, multiple sclerosis, and traumatic brain injury.

Non-invasive alternatives to surgery

Non-invasive therapies lead to fewer complications and require less post-procedure recovery compared to surgery. We have pioneered a technique that uses magnetic resonance guided focused ultrasound to remove tumours without surgery, and we are now investigating further areas where such techniques could be beneficial to patients.

Common imaging biomarkers to implement new treatments

Common imaging biomarkers can help guide researchers as they transform new treatment methods into clinical practice. Our development work concentrates on four main areas: respiratory disease, diabetes, cancer, and Crohn’s disease.

Imaging enables us to visualise anatomical, physiological and molecular biochemical changes non-invasively in patients and healthy people, helping us predict, monitor and treat diseases effectively, ultimately improving people’s quality of life.

Key Individuals
  • Professor Eric Aboagye
    Professor Eric Aboagye
    Theme Lead, Imaging
  • Dr Ben Ariff
    Dr Ben Ariff
    Consultant Cardiac Radiologist
  • Dr Daniel Rueckert
    Dr Daniel Rueckert
    Professor of Visual Information Processing
  • Dr Declan O'Regan
    Dr Declan O'Regan
    Honorary Clinical Senior Lecturer & Consultant Radiologist
  • Dr Deepa Gopalan
    Dr Deepa Gopalan
    Consultant Radiologist
  • Dr Edward Leen
    Dr Edward Leen
    Consultant Interventional Radiologist
  • Dr Laura Kenny
    Dr Laura Kenny
    Clinical Senior Lecturer in Medical Oncology
  • Dr Mengxing Tang
    Dr Mengxing Tang
    Reader in Biomedical Imaging
  • Dr Paul Edison
    Dr Paul Edison
    Clinical Senior Lecturer
  • Dr Rohini Sharma
    Dr Rohini Sharma
    Clinical Senior Lecturer/Consultant Medical Oncologist
  • Dr Sudhin Thayyil
    Dr Sudhin Thayyil
    Clinical Reader in Neonatology
  • Professor Andrea Rockall
    Professor Andrea Rockall
    Consultant Radiologist
  • Professor Andreja Frilling
    Professor Andreja Frilling
    Chair in Endocrine Surgery
  • Professor Nicholas Long
    Professor Nicholas Long
    Sir Edward Frankland BP Chair -Inorganic Chemistry
  • Professor Paola Piccini
    Professor Paola Piccini
    Professor of Neurology
  • Professor Tony Cass
    Professor Tony Cass
    Professor of Chemistry
  • Professor Wladyslaw Gedroyc
    Professor Wladyslaw Gedroyc
    Consultant radiologist
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