Award BRC ITMAT Awards 2019

The NIHR Imperial BRC has been supporting projects via the Institute for Translational Medicine and Therapeutics (ITMAT) scheme since 2015. This scheme aims to support projects that are highly likely to lead to a benefit for patients in Imperial College Healthcare NHS Trust, and/or follow-on funding or high impact publications. Over 4 previous rounds, a total of 55 projects have been supported which have resulted in £9.3M of leveraged funding to date.

In the latest call for applications which launched early in 2019, 6 new projects were selected for funding. These projects were reviewed by the ITMAT Committee, BRC Theme Leads, and members of the BRC Public & Patient Panel, with projects scored against a range of criteria including PPIE activities. The successful applicants will begin their projects in September 2019:

Lead Applicant	Project Title
Dr Shivani Misra	Improving stratification of young-onset diabetes: a multimodal, precision-based approach
Professor Guido Franzoso	Patient stratification to accelerate the clinical translation of the first-in-class GADD45β/MKK7 inhibitor, DTP3, in relapsed/refractory diffuse large B-cell lymphoma (DLBCL)
Dr Pinelopi Manousou	Open label single centre phase 2 trial of Faecal Microbial Transplantation in patients with Non Alcoholic Steatohepatitis and advanced fibrosis
Professor Tassos Karadimitris	Treating T cell lymphomas with TCRVβ subunit-specific chimaeric antigen receptor-engineered immune cells
Dr David Pinato	Qualification of antibiotic-induced gut perturbation as a therapeutically actionable driver of anti-cancer immunity
Dr Matthew Shun-Shin	Machine learning to support general physicians using hand-held echocardiography in acutely unwell patients: Leveraging Imperial’s large-scale outcome-linked, echocardiography dataset