25th September 2025

Stem cell dynamics in intestinal regeneration and colorectal cancer13:00 - 14:00Talk delivered by organoid and stem cell expert guest speaker from the Monash University (Australia) Prof Helen Abud The epithelial lining of the intestine is highly vulnerable to damage caused by infection and inflammation. Upon injury, stem cells have a remarkable capacity to promote epithelial repair. We have identified Neuregulin-1 (NRG1), an EGF family member, as a potent pro-regenerative factor that boosts intestinal stem cell proliferation and epithelial repair. Using mouse models and human intestinal organoids, we have found NRG1 modulates intestinal cell plasticity to promote epithelial regeneration and differentiation. We have also found that there are significant parallels between epithelial injury and colorectal tumour biology. We have discovered that key regulators of the epithelial repair process are also crucial in driving the recurrence of colorectal tumours. No registration required. Wolfson Lecture Theatre 2
Hammersmith Campus

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Stem cell dynamics in intestinal regeneration and colorectal cancer

Published on 11th September 2025 in
organoids_Leitch

25th September 2025

Stem cell dynamics in intestinal regeneration and colorectal cancer13:00 - 14:00Talk delivered by organoid and stem cell expert guest speaker from the Monash University (Australia) Prof Helen Abud The epithelial lining of the intestine is highly vulnerable to damage caused by infection and inflammation. Upon injury, stem cells have a remarkable capacity to promote epithelial repair. We have identified Neuregulin-1 (NRG1), an EGF family member, as a potent pro-regenerative factor that boosts intestinal stem cell proliferation and epithelial repair. Using mouse models and human intestinal organoids, we have found NRG1 modulates intestinal cell plasticity to promote epithelial regeneration and differentiation. We have also found that there are significant parallels between epithelial injury and colorectal tumour biology. We have discovered that key regulators of the epithelial repair process are also crucial in driving the recurrence of colorectal tumours. No registration required. Wolfson Lecture Theatre 2
Hammersmith Campus