Cancer

The NIHR Imperial BRC aims to improve personalised cancer and leukaemia care through the development of improved biomarkers for individual care and of therapies to overcome resistance to currently-used drugs. With the knowledge generated by the Centre, we are able to diagnose disease earlier and stratify patients into discrete groups for personalised treatment. Our research integrates information from the clinic with multidimensional omics techniques, as well as genetics, bioinformatics, and molecular imaging. We are developing systems approaches that underpin three main areas of work:

Complex clinical trials
Biomarker-based approaches have the potential to enable a stratified approach to therapy selection for patients with treatment-resistant disease. We test this potential via a range of complex clinical trials involving patients and clinicians.

Living with and beyond cancer
Following successful treatment with chemotherapy, radiotherapy, surgery, or bone marrow transplant, patients may still relapse. We are developing tests that can detect traces of residual disease, as well as those that predict autoimmune disease following bone marrow transplant.

New technologies to understand resistance to therapy
Many cancers will become resistant to therapies over time. We are working to understand the mechanisms behind the development of resistance. Our aim is to design drugs that prevent resistance from arising.

We work with a number of centres of excellence across Imperial College London, including the Cancer Research UK (CRUK) Imperial Centre, Imperial Experimental Cancer Medicines Centre, Ovarian Cancer Action Research Centre, and Bloodwise. This has enabled us to develop a translational research infrastructure that supports new research into optimising the patient journey, stratification of patients, and dynamic monitoring, phenotyping and modelling of cancers.

At the NIHR Imperial College Biomedical Research Centre, our facilities, and the techniques we have at our fingertips, enable us to carry out ground-breaking research. We have some of the best scientists and technical staff in the world, who use the most modern approaches to make rapid progress in this vitally important area of medical research.

Key Individuals
  • Professor Charles Coombes
    Professor Charles Coombes
    Theme Lead, Cancer
  • Professor Jane Apperley
    Professor Jane Apperley
    Chair of the Department of Haematology
  • Dr Aristeidis Chaidos
    Dr Aristeidis Chaidos
    Consultant Haematologist
  • Dr Danielle Power
    Dr Danielle Power
    Consultant Clinical Oncologist
  • Dr Dragana Milojkovic
    Dr Dragana Milojkovic
    Consultant Haematologist
  • Dr Harpreet Wasan
    Dr Harpreet Wasan
    Consultant Oncologist
  • Dr Holger Auner
    Dr Holger Auner
    Clinical Senior Lecturer
  • Dr Jesus Gil
    Dr Jesus Gil
    Professor of Cell Proliferation
  • Dr Matthew Fuchter
    Dr Matthew Fuchter
    Reader in Chemistry
  • Dr Nichola Cooper
    Dr Nichola Cooper
    Consultant Haematologist
  • Dr Niklas Feldhahn
    Dr Niklas Feldhahn
    Junior Bennett Fellow of Leukaemia & Lymphoma Research
  • Dr Simona Parinello
    Dr Simona Parinello
    Honorary Senior Lecturer
  • Dr Susan Cleator
    Dr Susan Cleator
    Oncologist
  • Prof Letizia Foroni
    Prof Letizia Foroni
    Professor of Haematology
  • Professor Anastasios Karadimitris
    Professor Anastasios Karadimitris
    Professor of Haematology
  • Professor Anthony Barrett
    Professor Anthony Barrett
    Head of Synthesis
  • Professor David Klug
    Professor David Klug
    Chair of the Institute of Chemical Biology
  • Professor David Rueda
    Professor David Rueda
    Chair of Molecular and Cellular Medicine
  • Professor Guido Franzoso
    Professor Guido Franzoso
    Chain in Inflammation and Signal Transduction
  • Professor Hani Gabra
    Professor Hani Gabra
    Professor of Medical Oncology
  • Professor Justin Stebbing
    Professor Justin Stebbing
    Professor of Cancer Medicine and Oncology
  • Professor Justin Vale
    Professor Justin Vale
    Consultant Urological Surgeon
  • Professor Martyn Boutelle
    Professor Martyn Boutelle
    Professor of Biomedical Sensors Engineering
  • Professor Michael Laffan
    Professor Michael Laffan
    Professor of Haemostasis & Thrombosis
  • Professor Michael Seckl
    Professor Michael Seckl
    Professor of Molecular Cancer Medicine
  • Professor Robert Brown
    Professor Robert Brown
    Head of Division of Cancer / Chair in Translational Oncology
  • Professor Wendy Atkin
    Professor Wendy Atkin
    Professsor of Gastrointestinal Epidemiology
  • Professor Yuri Korchev
    Professor Yuri Korchev
    Professor of Biophysics
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